Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
Tenovin-1
CAS: 380315-80-0
Molecular Formula: C20H23N3O2S
Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide - Names and Identifiers
Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide - Physico-chemical Properties
| Molecular Formula | C20H23N3O2S |
| Molar Mass | 369.48 |
| Density | 1.238±0.06 g/cm3(Predicted) |
| Melting Point | >180°C (Subl.) |
| Solubility | Soluble in DMSO (0.25 mg/ml), and DMF (0.25 mg/ml). |
| Appearance | solid |
| Color | White |
| pKa | 9.09±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Use | An inhibitor of SIRT1 and SIRT2. |
| In vitro study | Tenovin-1 is an activator of p53 and increases the amount of p53 protein within 2 hours of treatment. Tenovin-1 treatment did not change p53 mRNA levels. Tenovin-1 (10 μm) protected p53 from mdm 2 mediated degradation, and had little effect on p53 protein synthesis. Tenovin-1 acts on a group of p53 expressing tumor cells, inhibits cell growth, and induces apoptosis. They act by inhibiting the protein deacetylation activity of SirT1 and SirT2, two important members of the sirtuin family. Tenovin-1 is an activator of p53 and increases the amount of p53 protein within 2 hours of treatment. Tenovin-1 treatment did not change p53 mRNA levels. Tenovin-1 (10 μm) protected p53 from mdm 2 mediated degradation, and had little effect on p53 protein synthesis. Tenovin-1 acts on a group of p53 expressing tumor cells, inhibits cell growth, and induces apoptosis. They act by inhibiting the protein deacetylation activity of SirT1 and SirT2, two important members of the sirtuin family. |
| In vivo study | Initial in vivo experiments showed that Tenovin-1 impaired the growth of bl2-derived xenografts. initial in vivo experiments showed that Tenovin-1 impaired the growth of bl2-derived xenografts. |
Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide - Risk and Safety
| UN IDs | 3077 |
| HS Code | 29242990 |
Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide - Introduction
Tenovin-1 prevent MDM2-mediated degradation of p53, involving the ubiquitination pathway, by inhibiting the protein deacetylation activity of SirT1 and SirT2.
Last Update：2022-10-16 17:41:38
Tenovin 1 N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide - Reference Information
| biological activity | Tenovin-1 prevent MDM2-mediated degradation of p53, involving the ubiquitination pathway, by inhibiting the protein deacetylation activity of SirT1 and SirT2. Tenovin-1 can prevent MDM2-mediated degradation of p53, involves the ubiquitination pathway, and plays a role by reducing the deacetylation activity of SirT1 and SirT2 proteins. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH). |
| in vitro study | Tenovin-1 is p53 activator, which increases the amount of p53 protein within 2 hours of treatment. Tenovin-1 treatment did not change p53 mRNA level. Tenovin-1 (10 μM) protects p53 from mdm 2-mediated degradation and has little effect on p53 protein synthesis. Tenovin-1 acts on a group of tumor cells expressing p53, inhibits cell growth and induces cell apoptosis. It works by inhibiting the protein deacetylation activity of SirT1 and SirT2, two important members of the sirtuin family. Tenovin-1 is a p53 activator, which increases the amount of p53 protein within 2 hours of treatment. Tenovin-1 treatment did not change p53 mRNA level. Tenovin-1 (10 μM) protects p53 from mdm 2-mediated degradation and has little effect on p53 protein synthesis. Tenovin-1 acts on a group of tumor cells expressing p53, inhibits cell growth and induces cell apoptosis. It works by inhibiting the protein deacetylation activity of SirT1 and SirT2, two important members of the sirtuin family. |
| In vivo studies | Initial in vivo experiments showed that Tenovin-1 impairs the growth of BL2-derived transplanted tumors. initial in vivo experiments show that Tenovin-1 impairs the growth of BL2-derived transplanted tumors. |
| target | TargetValue p53 () Mdm2 () DHODH () |
| Target | Value |
Last Update：2024-04-09 21:31:58
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Spot supply
Product Name: Tenovin-1 Visit Supplier Webpage Request for quotationCAS: 380315-80-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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